histone h3 (h3) antibody Search Results


h3k18ac  (Cell Signaling Technology Inc)
95
Cell Signaling Technology Inc h3k18ac
H3k18ac, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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anti phosphohistone h3  (Cell Signaling Technology Inc)
98
Cell Signaling Technology Inc anti phosphohistone h3
Anti Phosphohistone H3, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 98/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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anti histone h3  (Cell Signaling Technology Inc)
99
Cell Signaling Technology Inc anti histone h3
Anti Histone H3, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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mouse anti p histone h3 antibody  (Cell Signaling Technology Inc)
98
Cell Signaling Technology Inc mouse anti p histone h3 antibody
Mouse Anti P Histone H3 Antibody, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 98/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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anti histone h3  (Santa Cruz Biotechnology)
96
Santa Cruz Biotechnology anti histone h3
Anti Histone H3, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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histone h3  (Bethyl)
93
Bethyl histone h3
Figure 1. Mutation or chemical inhibition of yeast HDACs suppresses TNR expansions. (A) Reporter with (CTG)20 permits expression of the reporter gene CAN1, and results in canavanine sensitivity. Expansions of $6 repeats alter transcription initiation, incorporating the out-of-frame ATG codon that blocks expression of CAN1 (X). Canavanine resistance ensues. (B) PCR products displayed on a high-resolution polyacrylamide gel. All expansion results reported here include PCR validation. (C) Expansion rates in mutants of Rpd3L (sin3 or pho23), Hda1 (hda3), or both (pho23 hda3 or sin3 hda3). TNR reporter integration sites are indicated in the figure. Error bars, 6SEM; * p,0.05 compared to wild type; + p,0.05 compared to wild type and to each single mutant (details in Table S1). (D) Cells were grown 13–14 generations in liquid culture 630 mg/ml TSA, followed by expansion analysis. Error bar, 6 SEM; * p = 0.02 compared to DMSO-only control, n = 5 independent measurements. (E) Accumulation of acetylated histone <t>H3</t> in yeast cells with impaired HDAC activity. Immunoblot results of 15 mg protein from whole cell lysates. Top, acetylated H3; bottom, total H3. Values below the blot show the ratio of acetylated H3/total H3. (F) Expansion sizes, derived from PCR analysis. 26 genetically independent expansions for wild type, 17 for sin3, 25 for hda3, and 8 for hda3 sin3. doi:10.1371/journal.pbio.1001257.g001
Histone H3, supplied by Bethyl, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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monoclonal antibody against ph3  (Santa Cruz Biotechnology)
94
Santa Cruz Biotechnology monoclonal antibody against ph3
Figure 1. Mutation or chemical inhibition of yeast HDACs suppresses TNR expansions. (A) Reporter with (CTG)20 permits expression of the reporter gene CAN1, and results in canavanine sensitivity. Expansions of $6 repeats alter transcription initiation, incorporating the out-of-frame ATG codon that blocks expression of CAN1 (X). Canavanine resistance ensues. (B) PCR products displayed on a high-resolution polyacrylamide gel. All expansion results reported here include PCR validation. (C) Expansion rates in mutants of Rpd3L (sin3 or pho23), Hda1 (hda3), or both (pho23 hda3 or sin3 hda3). TNR reporter integration sites are indicated in the figure. Error bars, 6SEM; * p,0.05 compared to wild type; + p,0.05 compared to wild type and to each single mutant (details in Table S1). (D) Cells were grown 13–14 generations in liquid culture 630 mg/ml TSA, followed by expansion analysis. Error bar, 6 SEM; * p = 0.02 compared to DMSO-only control, n = 5 independent measurements. (E) Accumulation of acetylated histone <t>H3</t> in yeast cells with impaired HDAC activity. Immunoblot results of 15 mg protein from whole cell lysates. Top, acetylated H3; bottom, total H3. Values below the blot show the ratio of acetylated H3/total H3. (F) Expansion sizes, derived from PCR analysis. 26 genetically independent expansions for wild type, 17 for sin3, 25 for hda3, and 8 for hda3 sin3. doi:10.1371/journal.pbio.1001257.g001
Monoclonal Antibody Against Ph3, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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rabbit anti ph3  (Cell Signaling Technology Inc)
95
Cell Signaling Technology Inc rabbit anti ph3
Figure 1. Mutation or chemical inhibition of yeast HDACs suppresses TNR expansions. (A) Reporter with (CTG)20 permits expression of the reporter gene CAN1, and results in canavanine sensitivity. Expansions of $6 repeats alter transcription initiation, incorporating the out-of-frame ATG codon that blocks expression of CAN1 (X). Canavanine resistance ensues. (B) PCR products displayed on a high-resolution polyacrylamide gel. All expansion results reported here include PCR validation. (C) Expansion rates in mutants of Rpd3L (sin3 or pho23), Hda1 (hda3), or both (pho23 hda3 or sin3 hda3). TNR reporter integration sites are indicated in the figure. Error bars, 6SEM; * p,0.05 compared to wild type; + p,0.05 compared to wild type and to each single mutant (details in Table S1). (D) Cells were grown 13–14 generations in liquid culture 630 mg/ml TSA, followed by expansion analysis. Error bar, 6 SEM; * p = 0.02 compared to DMSO-only control, n = 5 independent measurements. (E) Accumulation of acetylated histone <t>H3</t> in yeast cells with impaired HDAC activity. Immunoblot results of 15 mg protein from whole cell lysates. Top, acetylated H3; bottom, total H3. Values below the blot show the ratio of acetylated H3/total H3. (F) Expansion sizes, derived from PCR analysis. 26 genetically independent expansions for wild type, 17 for sin3, 25 for hda3, and 8 for hda3 sin3. doi:10.1371/journal.pbio.1001257.g001
Rabbit Anti Ph3, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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anti histone 3 abs  (Proteintech)
96
Proteintech anti histone 3 abs
Figure 1. Mutation or chemical inhibition of yeast HDACs suppresses TNR expansions. (A) Reporter with (CTG)20 permits expression of the reporter gene CAN1, and results in canavanine sensitivity. Expansions of $6 repeats alter transcription initiation, incorporating the out-of-frame ATG codon that blocks expression of CAN1 (X). Canavanine resistance ensues. (B) PCR products displayed on a high-resolution polyacrylamide gel. All expansion results reported here include PCR validation. (C) Expansion rates in mutants of Rpd3L (sin3 or pho23), Hda1 (hda3), or both (pho23 hda3 or sin3 hda3). TNR reporter integration sites are indicated in the figure. Error bars, 6SEM; * p,0.05 compared to wild type; + p,0.05 compared to wild type and to each single mutant (details in Table S1). (D) Cells were grown 13–14 generations in liquid culture 630 mg/ml TSA, followed by expansion analysis. Error bar, 6 SEM; * p = 0.02 compared to DMSO-only control, n = 5 independent measurements. (E) Accumulation of acetylated histone <t>H3</t> in yeast cells with impaired HDAC activity. Immunoblot results of 15 mg protein from whole cell lysates. Top, acetylated H3; bottom, total H3. Values below the blot show the ratio of acetylated H3/total H3. (F) Expansion sizes, derived from PCR analysis. 26 genetically independent expansions for wild type, 17 for sin3, 25 for hda3, and 8 for hda3 sin3. doi:10.1371/journal.pbio.1001257.g001
Anti Histone 3 Abs, supplied by Proteintech, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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anti acetyl h3k27 4353 antibodies  (Cell Signaling Technology Inc)
95
Cell Signaling Technology Inc anti acetyl h3k27 4353 antibodies
Figure 1. Mutation or chemical inhibition of yeast HDACs suppresses TNR expansions. (A) Reporter with (CTG)20 permits expression of the reporter gene CAN1, and results in canavanine sensitivity. Expansions of $6 repeats alter transcription initiation, incorporating the out-of-frame ATG codon that blocks expression of CAN1 (X). Canavanine resistance ensues. (B) PCR products displayed on a high-resolution polyacrylamide gel. All expansion results reported here include PCR validation. (C) Expansion rates in mutants of Rpd3L (sin3 or pho23), Hda1 (hda3), or both (pho23 hda3 or sin3 hda3). TNR reporter integration sites are indicated in the figure. Error bars, 6SEM; * p,0.05 compared to wild type; + p,0.05 compared to wild type and to each single mutant (details in Table S1). (D) Cells were grown 13–14 generations in liquid culture 630 mg/ml TSA, followed by expansion analysis. Error bar, 6 SEM; * p = 0.02 compared to DMSO-only control, n = 5 independent measurements. (E) Accumulation of acetylated histone <t>H3</t> in yeast cells with impaired HDAC activity. Immunoblot results of 15 mg protein from whole cell lysates. Top, acetylated H3; bottom, total H3. Values below the blot show the ratio of acetylated H3/total H3. (F) Expansion sizes, derived from PCR analysis. 26 genetically independent expansions for wild type, 17 for sin3, 25 for hda3, and 8 for hda3 sin3. doi:10.1371/journal.pbio.1001257.g001
Anti Acetyl H3k27 4353 Antibodies, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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h3k9m  (Cell Signaling Technology Inc)
93
Cell Signaling Technology Inc h3k9m
Figure 1. Mutation or chemical inhibition of yeast HDACs suppresses TNR expansions. (A) Reporter with (CTG)20 permits expression of the reporter gene CAN1, and results in canavanine sensitivity. Expansions of $6 repeats alter transcription initiation, incorporating the out-of-frame ATG codon that blocks expression of CAN1 (X). Canavanine resistance ensues. (B) PCR products displayed on a high-resolution polyacrylamide gel. All expansion results reported here include PCR validation. (C) Expansion rates in mutants of Rpd3L (sin3 or pho23), Hda1 (hda3), or both (pho23 hda3 or sin3 hda3). TNR reporter integration sites are indicated in the figure. Error bars, 6SEM; * p,0.05 compared to wild type; + p,0.05 compared to wild type and to each single mutant (details in Table S1). (D) Cells were grown 13–14 generations in liquid culture 630 mg/ml TSA, followed by expansion analysis. Error bar, 6 SEM; * p = 0.02 compared to DMSO-only control, n = 5 independent measurements. (E) Accumulation of acetylated histone <t>H3</t> in yeast cells with impaired HDAC activity. Immunoblot results of 15 mg protein from whole cell lysates. Top, acetylated H3; bottom, total H3. Values below the blot show the ratio of acetylated H3/total H3. (F) Expansion sizes, derived from PCR analysis. 26 genetically independent expansions for wild type, 17 for sin3, 25 for hda3, and 8 for hda3 sin3. doi:10.1371/journal.pbio.1001257.g001
H3k9m, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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anti phospho histone h3 thr11 primary antibody  (Cell Signaling Technology Inc)
93
Cell Signaling Technology Inc anti phospho histone h3 thr11 primary antibody
Figure 1. Mutation or chemical inhibition of yeast HDACs suppresses TNR expansions. (A) Reporter with (CTG)20 permits expression of the reporter gene CAN1, and results in canavanine sensitivity. Expansions of $6 repeats alter transcription initiation, incorporating the out-of-frame ATG codon that blocks expression of CAN1 (X). Canavanine resistance ensues. (B) PCR products displayed on a high-resolution polyacrylamide gel. All expansion results reported here include PCR validation. (C) Expansion rates in mutants of Rpd3L (sin3 or pho23), Hda1 (hda3), or both (pho23 hda3 or sin3 hda3). TNR reporter integration sites are indicated in the figure. Error bars, 6SEM; * p,0.05 compared to wild type; + p,0.05 compared to wild type and to each single mutant (details in Table S1). (D) Cells were grown 13–14 generations in liquid culture 630 mg/ml TSA, followed by expansion analysis. Error bar, 6 SEM; * p = 0.02 compared to DMSO-only control, n = 5 independent measurements. (E) Accumulation of acetylated histone <t>H3</t> in yeast cells with impaired HDAC activity. Immunoblot results of 15 mg protein from whole cell lysates. Top, acetylated H3; bottom, total H3. Values below the blot show the ratio of acetylated H3/total H3. (F) Expansion sizes, derived from PCR analysis. 26 genetically independent expansions for wild type, 17 for sin3, 25 for hda3, and 8 for hda3 sin3. doi:10.1371/journal.pbio.1001257.g001
Anti Phospho Histone H3 Thr11 Primary Antibody, supplied by Cell Signaling Technology Inc, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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Image Search Results


Figure 1. Mutation or chemical inhibition of yeast HDACs suppresses TNR expansions. (A) Reporter with (CTG)20 permits expression of the reporter gene CAN1, and results in canavanine sensitivity. Expansions of $6 repeats alter transcription initiation, incorporating the out-of-frame ATG codon that blocks expression of CAN1 (X). Canavanine resistance ensues. (B) PCR products displayed on a high-resolution polyacrylamide gel. All expansion results reported here include PCR validation. (C) Expansion rates in mutants of Rpd3L (sin3 or pho23), Hda1 (hda3), or both (pho23 hda3 or sin3 hda3). TNR reporter integration sites are indicated in the figure. Error bars, 6SEM; * p,0.05 compared to wild type; + p,0.05 compared to wild type and to each single mutant (details in Table S1). (D) Cells were grown 13–14 generations in liquid culture 630 mg/ml TSA, followed by expansion analysis. Error bar, 6 SEM; * p = 0.02 compared to DMSO-only control, n = 5 independent measurements. (E) Accumulation of acetylated histone H3 in yeast cells with impaired HDAC activity. Immunoblot results of 15 mg protein from whole cell lysates. Top, acetylated H3; bottom, total H3. Values below the blot show the ratio of acetylated H3/total H3. (F) Expansion sizes, derived from PCR analysis. 26 genetically independent expansions for wild type, 17 for sin3, 25 for hda3, and 8 for hda3 sin3. doi:10.1371/journal.pbio.1001257.g001

Journal: PLoS biology

Article Title: Histone deacetylase complexes promote trinucleotide repeat expansions.

doi: 10.1371/journal.pbio.1001257

Figure Lengend Snippet: Figure 1. Mutation or chemical inhibition of yeast HDACs suppresses TNR expansions. (A) Reporter with (CTG)20 permits expression of the reporter gene CAN1, and results in canavanine sensitivity. Expansions of $6 repeats alter transcription initiation, incorporating the out-of-frame ATG codon that blocks expression of CAN1 (X). Canavanine resistance ensues. (B) PCR products displayed on a high-resolution polyacrylamide gel. All expansion results reported here include PCR validation. (C) Expansion rates in mutants of Rpd3L (sin3 or pho23), Hda1 (hda3), or both (pho23 hda3 or sin3 hda3). TNR reporter integration sites are indicated in the figure. Error bars, 6SEM; * p,0.05 compared to wild type; + p,0.05 compared to wild type and to each single mutant (details in Table S1). (D) Cells were grown 13–14 generations in liquid culture 630 mg/ml TSA, followed by expansion analysis. Error bar, 6 SEM; * p = 0.02 compared to DMSO-only control, n = 5 independent measurements. (E) Accumulation of acetylated histone H3 in yeast cells with impaired HDAC activity. Immunoblot results of 15 mg protein from whole cell lysates. Top, acetylated H3; bottom, total H3. Values below the blot show the ratio of acetylated H3/total H3. (F) Expansion sizes, derived from PCR analysis. 26 genetically independent expansions for wild type, 17 for sin3, 25 for hda3, and 8 for hda3 sin3. doi:10.1371/journal.pbio.1001257.g001

Article Snippet: Primary rabbit antibodies were against histone H3 (A300-823A, Bethyl Laboratories), acetyl-histone H3 (#17-615, Millipore), acetyl-histone H4 (#06- 866, Millipore), b-actin (A2066, Sigma-Aldrich), HDAC3 (sc11417, Santa Cruz Biotechnology), and HDAC1 (CH00218, Coriell Institute for Medical Research).

Techniques: Mutagenesis, Inhibition, Expressing, Biomarker Discovery, Control, Activity Assay, Western Blot, Derivative Assay